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Explore cutting-edge testing and treatment solutions for eosinophilic diseases.
When you hear the word "allergy," sneezing, itchy noses, and watery eyes might come to mind. However, allergists today go beyond these symptoms to diagnose and treat complex immune system abnormalities. At our Eastlake office, we frequently address Inflammatory/Eosinophilic Diseases—conditions like hypereosinophilic syndrome (HES), severe eosinophilic asthma, eosinophilic pneumonia, and eosinophilic skin rashes. These diseases involve an overproduction of eosinophils, a type of white blood cell that can cause inflammation and damage.
Brian Modena and his expert team specialize in diagnosing and treating such eosinophilic conditions as well as other inflammatory diseases. Our focus includes eosinophilic granulomatosis with polyangiitis (EGPA) and various eosinophilic gastrointestinal diseases (EGID), such as eosinophilic gastritis (EoG), enteritis (EoN), and colitis.
Eosinophils, a type of white blood cell, play a critical role in our immune system. Historically, they helped fight parasitic infections in our gut and lungs. However, in countries like the U.S., where parasitic infections are rare, low eosinophil levels don't seem to impact us much. The exact purpose of eosinophils today remains unclear, but they are believed to regulate infections and promote wound healing.
Problems arise when eosinophils multiply excessively, invading tissues and causing damage. In the lungs, this can lead to eosinophilic pneumonia or severe asthma, making breathing difficult and affecting overall respiratory health. When eosinophils infiltrate tissues excessively, they cause inflammation and damage across various organs—a condition known as eosinophilic disease. In the esophagus, they can lead to swallowing difficulties or food impaction. In the digestive system, symptoms might include bloating and diarrhea. High levels are common among individuals with asthma or chronic sinus issues like
Hypereosinophilic syndrome (HES) is a rare condition where the body produces excess eosinophils, a type of white blood cell. These cells, while helpful in fighting parasites like intestinal worms, can lead to damage when they accumulate in tissues. Eosinophils also contribute to inflammatory diseases such as asthma, nasal polyps, sinusitis, and chronic skin rashes.
Despite their role in combating parasites, eosinophils may cause more harm than good today. HES often affects organs like the skin, lungs, digestive tract, heart, blood, and nervous system. Without treatment, it can become life-threatening.
When conditions like asthma or parasitic infections lead to increased eosinophil production, these are known as 'secondary' causes. The initial step is identifying and addressing any such secondary issues, such as treating a parasitic infection. The next consideration is whether active treatment is necessary or if monitoring suffices. If treatment is needed, options for primary (idiopathic) HES include steroids and Nucala® (mepolizumab). Depending on the type of HES and response to steroids, other treatments like Glivec® (imatinib), hydroxyurea, vincristine, cyclophosphamide, benralizumab, and interferon-alpha might be considered.
Dr. Modena and his team bring over a decade of expertise in managing allergic and eosinophilic disorders. Our pioneering research spans microbiome studies, genetics, inflammatory biomarkers, and cutting-edge AI applications to enhance personalized treatments. At Modena Allergy & Asthma, we're at the forefront of understanding eosinophilic disorders. We invite individuals with HES to join our latest clinical trial for innovative care options. If you're interested in learning more about this opportunity, please click the contact us button below.
Over the past decade, monoclonal antibody therapies have revolutionized medicine. Antibodies, naturally produced by our bodies, bind to harmful agents like viruses or bacteria, prompting our immune system to eliminate them. Leveraging new technology, scientists now design antibodies to target specific immune system parts, reducing inflammation and treating diseases. In Eastlake, we offer specialized antibody therapies for those with inflammatory or eosinophilic conditions, focusing on reducing eosinophils in the body.
Monoclonal antibody therapies offer a safer, more effective alternative to traditional steroid treatments for conditions like eczema, chronic sinusitis, nasal polyps, and asthma. At Modena Health, we tailor these therapies to meet your specific needs. Through comprehensive testing, we determine the precise treatment plan to manage your symptoms and restore your well-being.
Struggling with persistent sinus issues, asthma, eczema, or gastrointestinal concerns? It might be time to see an allergy specialist. At Modena Health in San Diego, Dr. Brian Modena and his team provide personalized care for inflammatory and eosinophilic diseases. Through detailed interviews, examinations, and targeted testing, they often diagnose rare conditions missed by others. Dr. Modena is renowned for his work in genomic research, continually seeking the best answers for his patients through investigational methods and targeted gene sequencing. Experience care that’s both innovative and tailored to your unique needs.
Before your first visit, it's essential for us to review any past medical notes, labs, or imaging. This helps enrich discussions with the doctor and streamlines the process. We kindly ask all patients to sign a Medical Release Form, which will be emailed to you. Once signed, we'll coordinate with your external doctor’s office to obtain your records. Modena Health may then order specialized labs and allergy skin testing for further evaluation. At a follow-up visit in 1-2 weeks, our expert team will discuss the results with you and develop a clear plan moving forward.
Recovery from inflammatory and eosinophilic diseases is unique to each person. While some may recover quickly, treatment often focuses on reducing flare-ups for lasting remission. If you have an eosinophilic condition, consulting with our allergy specialists can guide you in making the best treatment choices tailored to your needs.
New antibody therapies are revolutionizing the treatment of inflammatory and eosinophilic diseases by targeting eosinophils directly. Unlike traditional steroids, these treatments offer a safer and more effective alternative. Our practice has observed outstanding results with these therapies, providing hope for those seeking relief from persistent symptoms. Though individual responses can vary, our team is dedicated to finding the right solution for you.
Dr. Brian Modena and his expert team at Modena Health specialize in evaluating and treating eosinophilic disease and other inflammatory conditions in Eastlake. With a compassionate approach, they provide personalized care to help you manage your symptoms effectively. Schedule your consultation today to begin a path toward better health and well-being with the support of our dedicated professionals.
While the long-term effects of antibody therapies on eosinophilic conditions remain uncertain, these treatments are typically safer and more effective than steroids. By offering targeted and timely care, we aim to prevent permanent damage and alleviate symptoms, enhancing your quality of life.
Antihistamines are effective for relieving symptoms like an itchy nose or skin reactions. However, they are not suitable for treating inflammatory or eosinophilic conditions, which involve different pathways in the body. For these conditions, other treatments may be required to target the underlying inflammation rather than just alleviating surface symptoms. Always consult with a healthcare provider to determine the most appropriate treatment for your specific condition and needs.
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